DEVELOPMENT OF PERIPHERAL INSULIN RESISTANCE AS A CONSEQUENCE OF CENTRAL LEVERS OF INFLUENCE
DOI:
https://doi.org/10.32782/umv-2024.2.3Keywords:
insulin resistance, leptin resistance, gut microbiota, type 2 diabetes mellitus, metformin, pioglitazoneAbstract
The process of regulating intake and consumption to maintain energy balance is called lipostasis. Disruption of this system and metabolism can lead to disorders that may also cause changes in the structure of the gut microbiota.Insulin and leptin are key feedback signals. Their complex interaction with specific receptors in the central nervous system influences human eating behavior (pioglitazone) and leptin resistance (metformin) in patients with type 2 diabetes mellitus, helping to restore normal lipostatic function.
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