ANALYSIS OF BIOLOGICAL POTENTIAL OF 1,2,4-TRIAZOLE DERIVATIVES (LITERATURE REVIEW)
DOI:
https://doi.org/10.32782/umv-2023.2.4Keywords:
1,2,4-triazole, biological properties, activity.Abstract
In the current environment of development and formation of the pharmaceutical industry, it is important to constantly monitor the quality and safety of new synthetic medicines. Synthetic drugs have been an important tool for the prevention and treatment of various diseases for many years. Among synthetic substances, those that are low-toxic, safe and effective deserve special attention. Recent scientific publications confirm the prospects for finding new biologically active compounds among 1,2,4-triazole derivatives with different heterocyclic systems. Scientists argue that the combination of several structural fragments of heterocyclic compounds in one molecule leads to the emergence of new types of biological action and can enhance known pharmacological effects. Most of the synthesized compounds belong to the class of low-toxic or practically non-toxic substances. Aim. We are focused on analyzing foreign and domestic sources on the biological activity of 1,2,4-triazole derivatives and determining their characteristics. Materials and methods. The following methods were used in the study: analytical, information search, descriptive and generalization. To obtain the data, we reviewed the scientific literature to investigate the methods of synthesis and study the biological activity of 1,2,4-triazole derivatives containing aromatic and heterocyclic substituents. Results. We have searched, analyzed and summarized information on the methods of synthesis and study of the biological activity of 1,2,4-triazole derivatives with aromatic and heterocyclic substituents. After studying various sources of professional information and conducting a scientific search, it was found that the study of these 1,2,4-triazole derivatives with aromatic and heterocyclic substituents plays an important role in the pharmaceutical industry of Ukraine. These compounds are characterized by a wide range of pharmacological activity, have low acute toxicity and are promising for the development of new active pharmaceutical ingredients. Conclusion. The identified derivatives have been found to possess molecules with wide spectra of activity, such as antifungal and antimicrobial, antituberculosis, antihypoxic, antiviral and analgesic effects. The analysis of known data allowed us to establish structure-activity relationships. The results obtained may be relevant for further research.
References
Zhang, J., Wang, S., Ba, Y., & Xu, Z. (2019). 1,2,4-Triazole-quino-line/quinolone hybrids as potential anti-bacterial agents. European journal of medicinal chemistry, 174, 1–8. DOI: https://doi.org/10.1016/j. ejmech.2019.04.033
Zafar, W., Sumrra, S. H., & Chohan, Z. H. (2021). A review: Pharma-cological aspects of metal based 1,2,4-triazole derived Schiff bases. European journal of medicinal chemistry, 222, 113602. DOI: https://doi. org/10.1016/j.ejmech.2021.113602
Xu, Z. (2020). 1,2,3-Triazole-containing hybrids with potential anti-bacterial activity against methicillinresistant Staphylococcus aureus (MRSA). European journal of medicinal chemistry, 206, 112686. DOI: https://doi.org/10.1016/j.ejmech.2020.112686
Karpun Y, Fedotov S, Khilkovets A, Karpenko Y, Parchenko V, Klochkova Y, Bila Y, Lukina I, Nahorna N, Nahornyi V (2023). An in silico investigation of 1,2,4-triazole derivatives as potential antioxidant agents using molecular docking, MD simulations, MM-PBSA free energy calculations and ADME predictions. Pharmacia 70(1): 139–153. DOI: https://doi.org/10.3897/pharmacia.70.e90783
Shaykoon, M. S., Marzouk, A. A., Soltan, O. M., Wanas, A. S., Radwan, M. M., Gouda, A. M., Youssif, B., & Abdel-Aziz, M. (2020). Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives. Bioorganic chemistry, 100, 103933. DOI: https://doi.org/10.1016/j. bioorg.2020.103933[6]
Scarim, C. B., & Pavan, F. R. (2021). Thiazole, triazole, thio- and semicarbazone derivatives – Promising moieties for drug development for the treatment of tuberculosis. European Journal of Medicinal Chem-istry Reports, 1, 100002. DOI: https://doi.org/10.1016/j.ejmcr.2021.100002 7. Fedotov S., Gotsulya A., Zaika Ye., Brytanova T (2023). Design, synthesis and molecular docking of some derivatives of 9-methylpyrazolo[1,5-d][1,2,4]triazolo [3,4-f][1,2,4]triazine-3-thiol. J. Fac. Pharm. Ankara / Ankara Ecz. Fak. Derg., 47(2). DOI: https://doi.org/ 10.33483/jfpau.1180794 8. Qin, H. L., Zhang, Z. W., Ravindar, L., & Rakesh, K. P. (2020). Anti-bacterial activities with the structureactivity relationship of coumarin derivatives. European journal of medicinal chemistry, 207, 112832. DOI: https://doi.org/10.1016/j.ejmech.2020.112832
Bedane, K. G., Singh, G. S. (2015). Reactivity and diverse synthetic applications of acyl isothiocyanates. ARKIVOC, 206-245. DOI: http://dx.doi.org/10.3998/ark.5550190.p009.052
Moharana, A. K., Dash, R. N., & Subudhi, B. B. (2020). Thiosemicar-bazides: Updates on Antivirals Strategy. Mini reviews in medicinal chemistry, 20(20), 2135–2152. DOI: https://doi.org/10.2174/13895575206662008 18212408
Bihdan, O. A. (2021). Protymіkrobna ta protyhrybkova aktvnіst novykh ftorfenіlvmіsnykh 1.2.4-triazolіv [Antimicrobial and antifungal activity of new fluorophenyl-containing 1,2,4-triazoles]. Farmatsevtychnyi zhurnal, 76(2), 87–93. DOI: https://doi.org/10.32352/0367-3057.2.21.09 [in Ukrainian].
Karpun, Ye. O., & Polіshchuk, N. M. (2020). Protimіkrobna ta proti-gribkovikh novikh 4-(5-(((5-(alkіltіo)- 4-R-4 1H-1.2.4-trіazol-3-іl)pіridinі [Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R- 4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines]. Current is-sues in pharmacy and medicine: science and practice, 13(3), 354–358. DOI: https://doi.org/10.14739/2409-2932.2020.3.216204 [in Ukrainian].
Karpun E. O., & Parchenko, V. V. (2020). Syntez. fіzyko-khіmіchnі vlastyvostі ta antyhіpoksychna aktyvnіst deiakykh S-pokhіdnykh 4-R-5-(((3-(pіridin-4-іl)-1N-1.2.4-triazol-5-іl)tіo)metil)-4N-1.2.4-tri-azol-3- tіolіv [Synthesis, physicochemical properties and antigypoxic activity of some S-derivatives of 4-alkyl-5- (((3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol]. Farmatsevtychnyi zhurnal, 75(6), 56-64. DOI: https://doi.org/10.32352/0367-3057.6.20.06 [in Ukrainian].
Bilay, I. M., Galushko, A. J., Hnitko, I. V., Pruhlo, E. S., Kaplaushen-ko, A. G., Parchenko, V. V., Hotsulya, A. S., Panasenko, O. І., & Knish, E. G. (2013). Hіpolіpіdemіchna aktyvnіst deiakykh pokhіdnykh 1.2.4-trіazolu [Hypolipidemic activity of some 1,2,4-triazoles]. Current issues in pharmacy and medicine: science and practice, (1), 15–17 [in Ukrainian].
Demchenko, A. M., Yadlovskyi, O. Ye., Koval, A. Ya., Bobkova, L. S., Yanchenko, V. O., & Demchenko, D. A. (2016). 5,7-Diatsyl-3-n(alkil)-6-aryl-5N-[1,2,4]tryazolo[3,4-b][1,3,4]tiadiazyny, shcho proiavliaiut analhetychni vlastyvosti [5,7-Diacyl-3-H(alkyl)-6-aryl-5N-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazines exhibiting analgesic properties]. Ukraine Patent UA 112372. [in Ukrainian].
Ogorodnik, A. G., Yanchenko, V. A., Bobkova, L. S., Seredinska, N. M., & Demchenko, A. M. (2018). Syntez, ta analhetychni vlastyvosti pokhidnykh 5-metyl-3-aryl-[1,2,4]tryazolo[4,3-a]pirymydyn-7-olu [Synthesis and anаlgеsic activity 5-methyl-3-aryl[1,2,4]triazolo[4,3-a]pyrimidin-7-oles derivatives]. Farmatsevtychnyi Zhurnal, (2), 55–61. DOI: https://doi.org/10.32352/0367-3057.2.17.07 [in Ukrainian].
Chudinov, M. V., Prutkov, A. N., Matveev, A. V., Grebenkina, L. E., Konstantinova, I. D., & Berezovskaya, Y. V. (2016). An alternative route to the arylvinyltriazole nucleosides. Bioorganic & medicinal chemistry letters, 26(14), 3223–3225. DOI: https://doi.org/10.1016/j.bmcl.2016.05.072 18. Simurova, N. V., & Maiboroda, O. I. (2021). Antiviral activity of 1,2,4-tri-azole derivatives (microreview). Chemistry of heterocyclic compounds, 57(4), 420–422. DOI: https://doi.org/10.1007/s10593-021-02919-1
