THE ROLE OF ANGIOTENSIN-CONVERTING ENZYME AND ANGIOTENSINOGEN GENES POLYMORPHISM IN THE PATHOGENESIS OF ARTERIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
DOI:
https://doi.org/10.32782/umv-2023.2.10Keywords:
arterial hypertension, chronic obstructive pulmonary disease, angiotensin-converting enzyme, angiotensinogen, gene polymorphism.Abstract
Contradictory data on the role of renin-angiotensin-aldosterone gene polymorphisms, including angiotensinconverting enzyme (ACE) and angiotensinogen (AGT) genes in the development of cardiovascular pathology in people of different populations suggest further research. Most research in the field of genetics of hypertension or COPD focuses on one disease, however, given the similarities between the pathogenetic molecular mechanisms of COPD and hypertension, it is important to study the genetic basis of the formation of combined pathology. The aim of the study was to analyze scientific data on the role of angiotensin-converting enzyme (ACE), angiotensinogen (AGT) genes in hypertension and COPD. Currently, the M235T polymorphism of the AGT gene is associated with susceptibility to hypertension and coronary heart disease. Several studies have shown that insertion / deletion polymorphism in the ACE gene is associated with increased plasma ACE levels. Many studies have linked the ACE gene to essential hypertension. 60 % of the risk of COPD is due to hereditary genetic susceptibility. Genome-related studies have convincingly shown that COPD is a multifactorial polygenic disease. It is generally accepted that the gene encoding ACE is a candidate for susceptibility to COPD. Low ACE activity has been shown to play a significant role in the development of COPD, in particular the insertion / deletion polymorphism of the ACE gene is a promising locus in COPD susceptibility. Identification of specific genes and specific factors that interact to influence the development of hypertension, COPD and their combined course is of great interest to medicine. Despite the enormous progress made in studying the pathogenetic features of chronic obstructive pulmonary disease and hypertension, the challenge for scientists remains the desire to investigate the genetic basis of the comorbid course of these diseases.
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